The series follows a semi-fictionalized version of George Lopez and his day-to-day life, as he balances being a famous comedian while dealing with interpersonal relationships and trying to stay true to his roots in the Latino community. He also struggles to adjust to being a celebrity in a world where social media is a prevailing phenomenon.

• Lopez - Season 2
• John Altschuler
• Dave Krinsky
• George Lopez
• Jay Karas
• George Lopez
• Anthony Citric Campos
• Maronzio Vance